By Allan I. Basbaum (auth.), T. H. Stanley, M. A. Ashburn (eds.)
Anesthesiology and soreness Management comprises the edited shows of the thirty ninth Annual Postgraduate direction in Anesthesiology, February 1994. The chapters mirror new facts ideas in the basic framework of `pain study and easy science', and `clinical subject matters in ache management'. the aim of the textbook is to function a car to deliver the various most recent suggestions in anesthesiology to people who didn't attend the convention, inside a short while of the formal presentation. each one bankruptcy is a quick yet sharply targeted glimpse of the present pursuits in anesthesia. This quantity, in addition to earlier and destiny volumes, displays the fast and carrying on with evolution of anesthesiology within the overdue 20th century.
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Additional info for Anesthesiology and Pain Management
Because lidocaine base is poorly soluble, lidocaine solutions are prepared as an HCl salt to increase its solubility. On the other hand, carbonated salt solutions of lidocaine are prepared by bubbling C02 through a watery emulsion of lidocaine base in the cold. 5 (about the same as the plain hydrochloride solution). Unfortunately, carbonated local anesthetics are only commercially available in Canada and some other countries. 0, making more free base available for nerve penetration. The first two of these mechanisms are predicated on the rapid diffusion of C02 through the nerve membrane into the axoplasm.
GENERAL CONSIDERATIONS The clinically important properties of local anesthetics include potency, duration of action, speed of onset, and differential sensory/motor blockade. The clinical profile of the individual agents depends on their chemical structure, which determines their physico-chemical characteristics. The physico-chemical properties that influence anesthetic 35 T. H. Stanley and M. A. ), Anesthesiology and Pain Management, 35-M. © 1994 Kluwer Academic Publishers. 36 Table 1. Chemical structure of local anesthetics.
W 00 39 interact with a greater number of local anesthetic receptors and this may explain their inherently greater potency (3). In vivo studies in man indicate that the correlation between lipid solubility and anesthetic potency is not as precise as in an isolated nerve (Figure 1). Lidocaine is approximately twice as potent as prilocaine and mepivacaine in an isolated nerve preparation, but in man there is little difference in potency between these agents. Similarly, etidocaine is more potent than bupivacaine in isolated nerve, while clinically etidocaine is less potent than bupivacaine.