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By Kim D. Rainsford

Reviewing over a century of aspirin examine and use, Aspirin and comparable medicines presents a finished resource of data at the historical past, chemistry, absorption within the physique, healing results, toxicology, removing, and destiny makes use of of aspirin.Highlighting the old evolution of the salicylates and the economic improvement of aspirin, the e-book experiences the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a foundation for knowing the biodisposition of those analgesic medicinal drugs. major experts speak about the healing function of aspirin within the prevention and remedy of thrombo-embolic illnesses, its position besides non-acetylated salicylates within the therapy of rheumatic illnesses and simple, and the aptitude functions for aspirin and similar medications as prophylactics for colon melanoma, Alzheimer's affliction, and vascular dementia. additionally they current comparisons with different medicines used to regard discomfort and inflammation.With broad information and literature masking a large box, this is often the definitive reference at the activities and purposes of aspirin, salicylates, and comparable medications. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will locate this source priceless of their day-by-day paintings. it is going to even be helpful to pharmaceutical businesses and researchers within the improvement of more recent brokers and novel functions.

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1879, The treatment of acute rheumatism by salicin and salicylic acid. Lancet, ii: 875–877. J. 1880, Note on the danger attending the use of salicylic acid in acute rheumatism. Lancet, i: 327. A. 1880, The effect of salicylates on the heart. Lancet, i: 228. Margotta, R. 1968, An Illustrated History of Medicine (P. ). London: Paul Hamlyn. K. 1963, Significant factors in the history of aspirin. J. H. N. Wood (eds), Salicylates. An International Symposium, pp. 6–8. London: Churchill. H. 1884, Statistics of four hundred cases of rheumatism, with especial reference to treatment.

James, R. 1764, Pharmacopoeia Universalis: or A New English Dispensatory. 3rd Edition. London: Printed for T. Osborne et al. Jourdier, S. 1999, A miracle drug. htm. Keitel, W. 1977, 100 Jahre Anwendung der Salicylsäure und ihrer Derivate als Antirheumaticum. In: H. ), 100 Years of Salicylic Acid as an Antirheumatic Drug, pp. 39–50. Halle-Wittenberg: Martin-Luther Universitaet. Kemp, G. 1881, On the use and abuse of salicylic acid. British Medical Journal, i: 510. Kersch, 1880, Über Wirkung und Anwendung der Salicylsäure nach angestellten Versuchen an Thieren und am Krankenbette.

May, from the Mt Sinai Hospital New York, reported what was probably the largest set of data on the effects of salicylic acid compared with other popular remedies of the time (May, 1884). This study comprised 400 cases treated at the Roosevelt Hospital, New York. The patients had rheumatism (acute, subacute and chronic), but the study excluded those with muscular, syphilitic or gonorrhoeal rheumatism, and those with rheumatoid arthritis. These data are impressive, since they include full patient details, the time of year that patients were admitted, the duration of their treatments, their maximum temperatures, frequency of attacks, and relapses, and the frequency of cardiac valvular lesions, other complications and major outcomes.

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