By Robert E. Becker (auth.), Robert Becker, Ezio Giacobini (eds.)
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Additional info for Cholinergic Basis for Alzheimer Therapy
In: Biological Markers of Alzheimer's Disease, Boller F, Katzman R, Rascol A, Signoret J-L and Christen Y eds. Berlin: Springer-Verlag, pp. 1-16. Cholinesterases in Degenerative Diseases 37 Atack JR (1991): Aspects of acetylcholinesterase in human neurodegenerative disorders, particularly Alzheimer's disease. In: Clwlinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, Massoulie Jet al eds. In press. Atack JR, Perry EK, Bonham JR and Perry RH (1987): Molecular fonns of acetylcholinesterase and butyrylcholinesterase in human plasma and cerebrospinal fluid.
Therefore, updated evaluation methods for these parameters should be valuable to pharmacological research focused on the development and use of cholinergic drugs. Human CHEs are polymorphic carboxylesterase type B enzymes capable of rapidly terminating neurotransmission at cholinergic synapses and neuromuscular junctions (Soreq and Zakut, 1990). 8). Further classifications of CHEs are based on their Recombinant Cholinesterase in Drug Tests 47 hydrophobicity, interaction with membranes and multisubunit assembly.
In the normal cerebral cortex, the major effect of cholinesterase inhibitors is to enhance cholinergic neurotransmission. This cholinomimetic effect of cholinesterase inhibitions is likely to be attenuated in patients with AD who have a marked depletion of cortical cholinergic axons and cholinoceptive perikarya. In these patients, THA and physostigmine should have a substantial impact directly upon plaques, tangles and amyloid-containing vessels since most of these structures are intensely cholinesterase positive and since they frequently contain most of the cortical cholinesterase activity.