By Prof. Kian Fan Chung, John G. Widdicombe, Homer A. Boushey
Cough is the main widespread symptom of breathing affliction, and an issue which basic practitioners needs to take care of every day. This well timed quantity attracts jointly a wealth of contemporary examine into the mechanisms, pharmacology and cures for cough, and areas those in medical context. The textual content accommodates directions at the commonest explanations of cough, discusses remedies and pitfalls in administration, summarizes present examine on body structure, pharmacology and remedy of cough, and provides useful suggestion on analysis and administration matters for the clinician.
Cough: motives, Mechanisms and treatment is the main finished, updated account of the topic. it is going to replace scientific and easy clinical scientists, and advertise destiny learn. Readers are inspired to enforce the scientific implications of the dialogue into regimen perform. This quantity will entice all these serious about the remedy of respiration ailment, rather these in medical institution respiration devices, and also will be of use to basic practitioners.
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Additional info for Cough: Causes, Mechanisms and Therapy
Pulm Pharmacol Ther 2002; 15: 205–11. 23 Pavesi L, Subburaj S, Porter-Shaw K. Application and validation of a computerised cough acquisition system for objective monitoring of acute cough: a meta-analysis. Chest 2001; 120: 1121–8. 24 Lee PCL, Cotterill-Jones C, Eccles R. Voluntary control of cough. Pulm Pharmacol Ther 2002; 15: 317–20. 25 Eccles R. The powerful placebo. Do we need antitussives? Pulm Pharmacol Ther 2002; 15: 303–8. 26 Morice AH, Widdicombe J, Dicpinigaitis P, Groenke L. Understanding cough.
Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in the guinea pig. Am J Respir Crit Care Med 2002, 1071–5. 33 Carr MJ, Undem BJ. Inﬂammation induced plasticity of the afferent innervation of the airways. Environ Health Perspect 2001: 109 (Suppl. 4): 567–71. A. McGarvey Introduction Cough frequently accompanies the common cold and is usually self-limiting, causing little more than a nuisance . In this circumstance, many individuals selfmedicate, as is implied by the considerable annual expenditure on ‘over-the-counter’ antitussive preparations [2,3].
Functional morphology and physiology of rapidly adapting receptors (RARs). Anat Rec 2003; 270A: 2–10. 5 Sant’Ambrogio G, Widdicombe JG. Reﬂexes from airway rapidly adapting receptors. Respir Physiol 2001; 125: 33–45. 6 Karlsson J-A, Sant’Ambrogio G, Widdicombe JG. Afferent neural pathways in cough and reﬂex bronchoconstriction. J Appl Physiol 1988; 65: 1007–23. 7 Undem BJ, Carr MJ, Kollarik M. Physiology and plasticity of putative cough ﬁbres in the guinea pig. Pulm Pharmacol Ther 2002; 15: 193–8.